On the mechanism of cellular damage by shock waves: STUDENTS WANTED

Kadeem Dennis has defended his thesis on the mechanism of cellular damage by shock waves, titled " Mechanical Modification of Cells by Pressure Waves and its Application to Traumatic Brain Injury ". The preliminary study addresses the mechanism by which shock waves damage cells and may lead to traumatic brain injury (TBI). Fibroblasts (3T3) cell cultures were exposed to pressure waves produced by reacting thermite powder in water with different pressure amplitudes, ranging from 0.04 to 1.4 MPa peak pressures. Fluorescent images of the cells before and after pressure wave exposure were used to determine the type of damage suffered by the cells and whether the cells have died. Immediately after the exposure to the pressure waves, the cells were found to have their actin filament de-polymerized for all pressure waves tested. If allowed to recover for 60 minutes the 3T3 cells were found to have their actin re-polymerized. While the link ...